Arsenal celebrate going into this game having beaten Manchester United at Old Trafford 1-0 last Sunday, Emmanuel Adebayor supplying the finishing touch.
The Gunners should see Captain Thierry Henry available after a short period of absence through injury, whilst Robbie Van Persie should also start after recovering from his injury.
Teenage sensation Theo Walcott is likely to sit out with a shoulder injury which he picked up in the reserves.
As well as Walcott Arsenal face four more injuries; Gael Clichy (fractured metatarsal), Phillipe Senderos (shoulder), Vassiriki Abou Diaby (fractured ankle) and Etame Mayer Lauren (knee) will all miss the clash against the Blades.
Arsene Wenger told Arsenal TV Online: "Thierry is available and we should have Robin van Persie back too. We have no big injuries from last week. The other ones like Philippe Senderos, (Abou) Diaby, Lauren and (Gael) Clichy are not back yet but Henry is and Van Persie should be."
Possible Gunners Line-Up: Jens Lehmann, Johan Djourou, William Gallas, Emmanuel Eboue, Kolo Toure, Cesc Febregas, Tomas Rosicky, Freddrik Ljungberg, Alexandr Hleb, Gilberto Silva, Emmanuel Adebayor.
The Blades scraped through Tuesday night with a 1-0 victory over League Two side Bury in the Second Round of the Carling Cup; Franch striker Christian Nadé putting the Blades through.
Arsenal didn't feature in the Carling Cup due to Champions League involvement - but will join in the next round; but the time the Gunners play the Blades the draw will have been made but the two teams could end up facing each other once again.
United travel to the Emirates Stadium with nine casualties; Steven Kabba, Danny Webber (both hamstring), Paddy Kenny, Craig Short (both thigh), Derek Geary (groin), Neil Shipperley (knee), Michael Tonge (ankle), Alan Wright (calf) and Nick Montgomery (ankle).
Possible Blades Line-up: Ian Bennett, Leigh Bromby, Chris Morgan, Claude Davis, David Unsworth, Paul Ifill, Phil Jagielka, Alan Quinn, Chris Armstrong, Rob Hulse, Ade Akinbiyi.
Referee: Alan Wiley (Staffordshire)
- 03 Mar 1998 - Sheffield United 0-1 Ipswich Town
- 12 Sep 1998 - Bradford City 2-2 Sheffield United
- 02 Jan 1999 - Sheffield United 1-1 Nott's County (FAC3)
- 23 Jan 1999 - Nott's County 3-4 Sheffield United (FAC3r)
- 01 Jan 2001 - Sheffield United 1-3 Manchester City
- 03 Dec 2002 - Sheffield United 2-0 Sunderland (LC)
- 21 Jan 2003 - Liverpool 2-0 Sheffield United (LCSF)
- 11 Sep 2004 Sheffield United 1-2 West Ham United
- 21 Oct 2005 Leeds United 1-1 Sheffield United
Blades-Mad Prediction: Arsenal 0-0 Sheffield United