Of course, United won't lose there lead at the top of the Championship as they are left four points clear of second placed Reading.
United go into the game after an excellent 2-0 victory over Ipswich Town at Bramall Lane. Steven Kabba slashed in the first, beating Lewis Price on far post after five minutes before running onto Alan Quinn's in 90th minute to make in 2-0.
However in between then Kabba brought down Luis Cisto Sito in the box only to see Darren Currie's effort saved by Paddy Kenny before Cistro Sito was sent off for two book able offences.
The Blades will still be without striker Danny Webber who still suffers from that calf strain, this is the third match the Blades have missed the former Watford striker.
United will also be without front man Paul Shaw who is out with an Achilles injury. The former Gillingham striker netted at the Withdean last season as the Blades drew 1-1 with the seagulls.
Keith Gillespie, who was kept on the bench during the victory over Ipswich may start ahead of Paul Ifill who was replaced by the Northern Ireland International after receiving two knocks. Other unpredicted changes could be made with the vital trip to third place Watford looming next Saturday.
Blades Possible Starting Line-Up: Paddy Kenny, Leigh Bromby, Craig Short, Chris Morgan, David Unsworth, Keith Gillespie, Phil Jagielka, Nick Montgomery, Alan Quinn, Neil Shipperley, Steven Kabba.
Albion saw their game with Leeds United at Elland Road end 3-3 with the Whites leveling in the last minute last Saturday.
Mark McGhee's men saw them take a 2-0 lead through former Wednesday striker Leon Knight (28 minutes) and Sebastian Carole on 51 before a David Healy double on 65 and 70 minutes made it 2-2.
The visitors thought they had gone away with all three points when Sean Gregan turned the ball into his own net with seven minutes left after a low cross had been plowed into the box. But it was the West Yorkshire club who had the last say, Jason Douglas converting the rebound deep into injury time.
The Seagulls will be without former Southampton full-back Jason Dodd who is expected to be out for six weeks with an ankle injury whilst Argentinean Winger Alexandre Frutos has recovered from a knee problem and could be in line to make his debut following his recent transfer from Metz before the transfer window closed.
However McGhee is boosted by the return of full-back Kerry Mayo who completed 90 minutes of football in last weeks reserve game against Reading.
Mayo, who has been out with a calf injury played centre-back during the 2-0 defeat to the Royals.
Seagulls Possible Starting Line-Up: Wayne Henderson, Paul Reid, Guy Butters, Paul McShane, Dean Hammond, Gary Hart, Richard Carpenter, Sebastian Carole, Albert Jarrett, Jake Robinson, Leon Knight.
:: Head-to-Head ::
|Brighton & Hove Albion v Sheffield United (all competitions)|
:: Last 6 Meetings ::
15.01.2005 Blades 1-2 Seagulls
02.10.2004 Seagulls 1-1 Blades
18.03.2003 Blades 2-1 Seagulls
19.10.2003 Seagulls 2-4 Blades
14.03.1990 Seagulls 2-2 Blades
09.09.1989 Blades 5-2 Seagulls
Championship Fixtures (7:45pm Kick-Off unless stated)
Tuesday (13.09.2005): Brighton & Hove Albion v Sheffield United, Cardiff City v Leicester City, Hull City v Stoke City, Ipswich Town v Southampton, Plymouth Argyle v Crewe Alexandra, Preston North End v Burnley, Queens Park Rangers v Luton Town, Reading v Crystal Palace, Sheffield Wednesday v Leeds United, Watford v Norwich City, Wolverhampton Wanderers v Millwall.
Wednesday (14.09.2005): Derby County v Coventry City