Second placed Reading are attempting to chase six points which is currently the gap between the two clubs after there goalless draw with Southampton last Wednesday.
After missing the 1-0 victory over Norwich City last Saturday Sekou Baradji (on loan from West Ham United) is fit again after recovering from an ankle problem.
Steve Coppell however faces a selection problem and may turn to skipper Greame Murty, the former York City defender is all ready injured but may have to play through the pain barrier to make up the strong squad.
Adam Federici is likely to make the bench, the keeper has recently signed a professional contract with the Royals after coming through the youth ranks but is unlikely to keep American Marcus Hehnemann from between the sticks.
Despite the presence of Leroy Lita the Madejski Stadium club are expected to be without striker Dave Kitson, defender Nicky Shorey and midfielder Steve Sidwell through injury. The trio are all key players in the Reading line-up and are not expected to return until after the International weekend.
Possible Royals Line-Up: Marcus Hehnemann, Ivar Imgirmarsson, Chris Makin, Graeme Murty, Ibrahim Sonko, Brynjar Gunnarsson, Bobby Convey, Glen Little, James Harper, Kevin Doyle, Leroy Lita.
United go into the game top of the league after beating Plymouth Argyle 2-0 last Tuesday at Bramall Lane, Neil Shipperley and Alan Quinn getting on the score sheet.
The Blades look to go into the game unchanged as Neil Warnock has no injury worries in his line-up, therefore it is expected the same starting eleven will line up that beaten Derby County (2-1) and Plymouth (2-0) at Brammall Lane.
However United could call upon the services of Vincent Pericard, the striker who is on loan from Portsmouth came off the bench in the two previous games. He could be moved upfront to replace Shipperley who could struggle with the Royals strong physical presence.
After recovering from an hamstring injury former Everton defender Craig Short will be looking to push his way back into the side but faces competition from Robert Kozluk who has been outstanding whilst supporting the full-back position.
Possible Blades Line-Up: Paddy Kenny, Robert Kozluk, Leigh Bromby, Chris Morgan, David Unsworth, Paul Ifill, Phil Jagielka, Nick Montgomery, Alan Quinn, Neil Shipperley, Steven Kabba.
:: Championship Fixtures ::
01.10.05: Brighton & Hove Albion v Norwich City, Cardiff City v Luton Town, Derby County v Leicester City, Ipswich Town v Crewe Alexandra, Plymouth Argyle v Stoke City, Preston North End v Southampton, Reading v Sheffield United, Sheffield Wednesday v Coventry City, Watford v Leeds United.
03.10.05: Queens Park Rangers v Crystal Palace.