The Blades go into the game after a heavy 3-0 defeat at Arsenal, in Neil Warnock's 1,000 Football League game as a manager he saw William Gallas take in the lead after 65 minutes along with a Phil Jagielka own goal (69) and Thierry Henry (81) adding the finishing touch.
United should welcome back striker Steve Kabba who has recovered from a hamstring injury and after coming off the substitutes bench at the Emirates Stadium will be looking to push for a place upfront with Rob Hulse.
Neil Warnock however will have to contend with six players out injury; one key player missing is keeper Paddy Kenny who is out with a thigh injury and is not clear as to when we will be back.
Elsewhere Neil Shipperley (knee), Nick Montgomery (ankle), Danny Webber (hamstring), Michael Tonge (ankle) and Chris Short (thigh) will all miss the tie with Middlesbrough.
Possible Blades Line-Up: Ian Bennett, Leigh Bromby, Claude Davis, David Unsworth, Derek Geary, Paul Ifill, Phil Jagielka, Mikele Leighterwood, Alan Quinn, Steven Kabba, Rob Hulse.
Boro manager Gareth Southgate goes into this game trying to overturn the 1-0 defeat inflicted upon them last Saturday by Blackburn Rovers. On loan striker Shabani Nonda (AS Roma) netted the winner on 27 minutes.
They should see England Winger Stuart Downing return to the fold, he has been suffering with a groin injury but may make the substitutes bench in their trip to Bramall Lane.
Meanwhile the Reds will be without Chris Riggott (ankle), Ugo Ehiogu (Achilles), Julio Arca (broken foot) and captain George Boateng (knee).
Former Sunderland defender Julio Arca has returned to light training but will not make the trip to South Yorkshire.
Possible Boro Line-Up: Mark Schwarzer, Jonathan Woodgate, Emmanuel Pogatez, Stuart Parnaby, Andrew Taylor, Andrew Davies, Fabio Rockemback, James Morrison, Gaizka Mendieta, Jason Euell, Yakubu Ayegbani.
Referee: P. Walton (Northamptonshire) - Including the 2-0 defeat which the Blades endured at Tottenham Hotspur this season; referee Mr. Walton has took charge of eight games which involve the Blades.
- 23.10.2001 - Preston North End 3-0 Blades
- 15.05.2003 - Blades 4-3 Nottingham Forest (Play-Off)
- 21.10.2003 - Wigan Athletic 1-1 Blades
- 22.01.2005 - Sunderland 1-0 Blades
- 05.04.2005 - Leeds United 0-4 Blades
- 08.05.2005 - Wolverhampton 4-2 Blades
- 18.10.2005 - Millwall 0-4 Blades
- 22.08.2006 - Tottenham Hotspur 2-0 Blades
Blades-Mad Prediction: Sheffield United 2-1 Middlesbrough