The Latics, on Wednesday night were unlucky not claim a point at home to Arsenal who were undone just two minutes from time via a Emmanuel Adebayor effort.
Wigan, who play Sheffield United for the first time in both the clubs history at top flight level will be without five key players.
Former Barnsley and Portsmouth defender Arjan de Zeeuw is out with a toe injury but could be in contention for the game on Saturday. Meanwhile Gary Teale and Luis Antonio Valencia are both out of action with hamstring injuries.
Also out of action for the JJB club is Ryan Taylor and veteran keeper John Filan (aged 36) who will sit out the game to a broken leg and groin injury respectively.
Defender Paul Scharner will return to action for the Lancashire side; the former SK Brann player picked up five yellow cards and was suspended for the fixture against Arsenal.
Predicted Latics Line-Up: Chris Kirkland, Leighton Baines, David Wright, Emmerson Boyce, Fitz Hall, Kevin Kilbane, Denny Landzaat, Josip Skoko, Emile Heskey, Henri Camara, Lee McCulloch.
Sheffield United lined up for the camera's last Monday night as they entertained Aston Villa. It was a dogged affair as the teams shared the spoils with a 2-2 draw.
Stilan Petrov got off the marks within 70 seconds, breaking the Blades defence before slamming the ball home. United had a poor first half but woke up in the second and after five minutes were level, young Stephen Quinn volleying home after a timely throwing.
Blades then took the lead through Danny Webber who was able to flick into the top corner before, on 65 minutes Milan Baros went straight up the pitch and levelled the score.
United are fortunate that along with Manchester United are the only Premier League team to not be suffering from injuries; unlike Newcastle United who list 13 casualties to their name.
The Blades welcome back Alan Quinn and Claude Davis who return from injury and sat on the bench during the draw with the Claret and Blue but were unused substitutes. Alan could get into the side on Saturday but the impressive performances of his brother Stephen may rule him out.
Michael Tonge (we believe) will be a secret addition to the United line-up, Tonge hasn't played since he came off against Chelsea on 28 October with an ankle injury. He has been in training and believe that he will play some part in this game.
On the Cutlers side against Wigan will be former Latic Keith Gillespie. Whilst at Manchester United the Northern Ireland international joined Athletic on loan, playing ten games and scoring four goals in September 1993. Robert Kozluk also joined Wigan in September 2001 on loan from the Blades but failed to make and appearance.
Predicted Blades Line-Up: Paddy Kenny, Leigh Bromby, Claude Davis, Chris Morgan, Derek Geary, Keith Gillespie, Phil Jagielka, Michael Tonge, Stephen Quinn, Rob Hulse, Danny Webber.
Man in the Middle: P. Walton (Northampton)
After refereeing Sheffield United's Premier League encounters against Tottenham Hotspur (L 0-2) and Middlesbrough (W 2-1) this will be match official Mr. Walton's third Blades game in charge.
- 23.10.2001 - Preston North End 3-0 Blades
- 15.05.2003 - Blades 4-3 Nottingham Forest (Play-Off)
- 21.10.2003 - Wigan Athletic 1-1 Blades
- 22.01.2005 - Sunderland 1-0 Blades
- 05.04.2005 - Leeds United 0-4 Blades
- 08.05.2005 - Wolverhampton 4-2 Blades
- 18.10.2005 - Millwall 0-4 Blades
- 22.08.2006 - Tottenham Hotspur 2-0 Blades
- 30.09.2006 - Blades 2-1 Middlesbrough
Blades-Mad Prediction: Wigan Athletic 1-1 Sheffield United