Wales; ranked 116th in the FIFA World Rankings face a determined England (ranked 6th) side who plan ripping their neighbours apart as they aim to qualify for the European Championships next year.
England currently lay second in the Group G qualification table; three points behind table toppers Montenegro and have a game in hand after two wins and a draw from their three matches played.
Meanwhile Wales are bottom without any points, also having played three matches – Switzerland and Bulgaria are the other two teams which make up our five team group.
England boss Fabio Capello has featured three former Sheffield United players in his squad to face Wales this weekend; Phil Jagielka, Gary Cahill and Kyle Walker could also feature at some point during the 90 minutes.
He has named a strong squad to face the Dragons in Cardiff but has left out Manchester United skipper Rio Ferdinand –handing the captaincy back to John Terry.
Wales boss Gary Speed has named two players known to Blades fans; Ched Evans – who has scored nine goals for the Bramall Lane club this season and Sam Vokes who has recently enjoyed a loan spell from Wolverhampton Wanderers.
Arsenal midfielder Aaron Ramsey has been included in the squad to face England for the first time since November 2009 when he broke his leg and was sidelined for over a year.
Celtic midfielder Joe Ledley is also in the squad; he scored in the Scottish League Cup Final at Hampden Park last Sunday as the Hoops lost 2-1 in extra time to dearest rivals Rangers.
England: Ben Foster (Birmingham), Joe Hart (Manchester C), Robert Green (West Ham), Leighton Baines (Everton), Gary Cahill (Bolton), Ashley Cole (Chelsea), Michael Dawson (Tottenham), Phil Jagielka (Everton), Glen Johnson (Liverpool), Joleon Lescott (Manchester C), John Terry (Chelsea), Kyle Walker (Tottenham), Gareth Barry (Tottenham), Stewart Downing (Aston Villa), Matt Jarvis (Wolves), Frank Lampard (Chelsea), Aaron Lennon (Tottenham), James Milner (Manchester C), Scott Parker (West Ham), Jack Wilshire (Arsenal), Ashley Young (Aston Villa), Darren Bent (Aston Villa), Andy Carroll (Liverpool), Peter Crouch (Tottenham), Jermaine Defoe (Tottenham), Wayne Rooney (Man Utd).
Wales: Wayne Hennessey (Wolves), Boaz Myhill (WBA), Lewis Price (Crystal Palace), Danny Collins (Stoke), James Collins (Aston Villa), Neal Eardley (Blackpool), Danny Gabbidon (West Ham), Chris Gunter (Nottingham Forest), Lewin Nyatanga (Bristol City), Neil Taylor, Ashley Williams, Joe Allen (all Swansea), Gareth Bale (Tottenham), Andrew Crofts (Norwich), Andy King (Leicester), Joe Ledley (Celtic), Aaron Ramsey (Arsenal), David Vaughan (Blackpool), Craig Bellamy (Man City), Simon Church (Reading), Sam Vokes (Wolves), Ched Evans (Sheffield United), Freddie Eastwood (Coventry), Steve Morison (Millwall), Hal Robson-Kanu (Reading).