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Wanderers manager Mick McCarthy will be without keeper Matt Murray (tendon), who has returned from his loan spell at Hereford United following his injury - George Elokobi (knee), Mark Little (meniscal) and Daniel Jones (ankle) are also missing due to injury.
Striker Chris Iwelumo who netted twice in the Wolves 3-1 win at Bramall Lane in November has returned from a ankle injury and was available on the bench for their win over Rovers, he replaced Andy Keogh shortly after hat-time and is likely to start against the Blades.
Possible Wolves Line-Up: Wayne Hennessey, Richard Stearman, Neill Collins, Matt Hill, Kevin Foley, Michael Knightly, David Edwards, Karl Henry, Stephen Ward, Sylvan Ebanks-Blake, Chris Iwelumo.
Sheffield United travel to the Midlands having claimed points on the road in their previous six outings; their fine run began on 28th October when they drew 0-0 at Bristol City and since then have claimed points at; Barnsley (won 2-1), Charlton Athletic (won 5-2), Ipswich Town (drew 1-1), Nottingham Forest (won 1-0) and Swansea City (drew 1-1), picking up twelve points in the process. The last time the Blades lost on their travels was a 1-0 defeat at Sheffield Wednesday.
Blades boss Kevin Blackwell is without veteran midfielder Gary Speed (back) who made his Blades debut at Molineux last season on 1st January, then they drew 0-0. United will also be without striker Darius Henderson who serves the second of a three match suspension, he will also miss next Sunday's home fixture against Charlton Athletic.
Fellow striker James Beattie, who has netted 11 goals this season so far is carrying a calf strain and may not feature against the Championship's heavyweight club. Meanwhile Nick Montgomery (who returned to action last Saturday) is out with a calf strain and Gary Naysmith (back) is also expected to be missing from action.
Possible Blades-Line-Up: Paddy Kenny, Kyle Naughton, Chris Morgan, Ugo Ehiogu, Matthew Kilgallon, Nathan Dyer, Matthew Spring, Brian Howard, Stephen Quinn, Danny Webber, James Beattie.