With West Ham United and Charlton Athletic losing their games against Watford (1-0) and Manchester United (2-0) Sheffield United went 10 points clear of the relegation zone with Wigan Athletic still to face Arsenal on Sunday.
The visitors got off to a clear start; scoring as early as the second minute via Jermaine Jenas who raced onto Robbie Keane's flick to chip over Paddy Kenny.
But, on 27 minutes Rob Hulse levelled the score when he headed in Colin Kazim-Richards corner - whilst in the second half Phil Jagielka powered in his spot kick to give the Blades a deserved victory.
United have so far this season faired well against London clubs this season, despite claiming a point in the Capital the Blades have (with the exception of Chelsea) yet to lose a fixture at Bramall Lane during the course of the 2006/07 season.
This isn't a bad record considering they have beaten Arsenal (1-0) on home territory, whilst they have overcame Charlton Athletic (2-1), Tottenham Hotspur (2-1) and Fulham (2-0) only Chelsea (0-2) have won at Bramall Lane and West Ham United (14 April) have yet play in Sheffield.
The win didn't look possible when, from the start the visitors dominated and took charge of the Blades half for nigh on 20 minutes - during that time they took the lead.
Keane, who is arguably one of the best strikers in the Premier League flicked over the defence for Jenas, who when one-on-one with the keeper knocked over Paddy Kenny to score.
Teemu Tainio then slipped a pass through to Keane who should have squared across goal - Thankfully he was too greedy and went for goal, scrapping the post as is skimmed wide with Berbatov unmarked.
The Republic of Ireland international then set up strike partner Dimitar Berbatov but the Bulgarian's headed sailed wide of goal.
United were to go on and win the game but made heavy weather of it, and only started to get into the game after twenty minutes, the Blades had several attempts on goal and had won aerial challenges. They thought they had the ball in the net when Kazim-Richards launched in a cross only for Hulse's bulleting header to bounce back off the bar with no one to follow up.
The ball looked to have crossed the line but replay's suggest otherwise. Rob Hulse had been unlucky in his previous two outings for the Blades (v Fulham and Blackburn) having seen an attempt in each game find its way to the woodwork.
However there was to be no mistaking the equaliser, he once again was first to a Colin Kazim-Richards corner, the ball beat Matt Dawson and Richardo Roche and the ball nestled into the far bottom corner.
From then on United took full charge of the game and fellow forward Jonathan Stead twice fired decent efforts wide of goal.
Jermaine Jenas fired wide after good manoeuvres from Berbatov and former Fulham midfielder Steed Malbranque. And, Blades hearts fell when Roche beat the Blades to the ball to fire past Kenny into the net only to be saved by the Assistant Referee who jugged that Malbranque committed a foul on Stead.
In the second half referee Martin Atkinson had no choice to award a penalty when Tainio mugged Stephen Quinn just inside the box, captain Phil Jagielka stood up and like he did at Middlesbrough on new year's day crashed home the spot kick.
Chris Lucketti and substitute Jermaine Defoe were both booked after both players were involved in an ugly spat.
A double Egyptian substitution was made with Ahmed Fathi (for Colin Kazim-Richards) making his Blades debut whilst Spurs threw on Ahmed Mido in place of Malbranque, and in an act of desperation went with a four pronged attack which failed to impress.
United however held on for there eighth win of the Premier League season and moved ten points clear of the drop zone.